Epigastric pain DDX
GERD → Burning epigastric/chest pain worse after meals or lying flat with regurgitation, usually improves with antacids/PPI and normal workup.
Gastritis → Burning epigastric pain with nausea/bloating often related to NSAIDs or alcohol, differentiated by H. pylori testing or EGD.
Peptic Ulcer Disease (PUD) → Gnawing epigastric pain related to meals with possible melena/anemia, diagnosed with H. pylori testing and EGD.
Perforated Ulcer → Sudden severe epigastric pain with rigid abdomen/peritonitis, differentiated by free air on upright CXR or CT.
Pancreatitis → Severe epigastric pain radiating to the back with nausea/vomiting, diagnosed by lipase >3× normal.
Biliary Colic → Episodic RUQ/epigastric pain after fatty meals without fever, differentiated by gallstones on RUQ ultrasound.
Acute Cholecystitis → Persistent RUQ/epigastric pain with fever and Murphy sign, diagnosed by gallbladder wall thickening/pericholecystic fluid on ultrasound.
Choledocholithiasis → Epigastric/RUQ pain with jaundice and cholestatic LFTs, differentiated by biliary obstruction on MRCP/ERCP.
Ascending Cholangitis → Fever, jaundice, and RUQ/epigastric pain (Charcot triad), diagnosed with cholestatic labs and biliary dilation.
Hepatitis → Epigastric/RUQ discomfort with jaundice, fatigue, and dark urine, differentiated by markedly elevated AST/ALT.
ACS / Inferior MI → Epigastric pain with diaphoresis, dyspnea, or exertional symptoms especially in elderly/diabetics, diagnosed with EKG and troponins.
Aortic Dissection → Sudden tearing epigastric/chest pain radiating to the back, diagnosed by CTA.
Mesenteric Ischemia → Severe epigastric pain out of proportion to exam often with AFib history, differentiated by elevated lactate and CTA.
Functional Dyspepsia → Chronic epigastric discomfort/fullness with normal labs/imaging, diagnosed after exclusion of organic causes.
Gastroparesis → Early satiety, bloating, nausea, and epigastric discomfort especially in diabetics, diagnosed with gastric emptying study.
Gastroenteritis → Epigastric/crampy abdominal pain with vomiting and diarrhea, usually diagnosed clinically.
Small Bowel Obstruction → Crampy abdominal/epigastric pain with vomiting and distention, diagnosed by CT showing dilated bowel loops.
DKA → Epigastric pain with vomiting, polyuria, and altered mentation, differentiated by anion-gap acidosis and ketones.
AAA → Epigastric/back pain with hypotension or pulsatile mass, diagnosed rapidly with bedside ultrasound or CTA.
Esophagitis → Burning epigastric/chest pain with odynophagia, diagnosed by EGD.
Boerhaave Syndrome → Severe chest/epigastric pain after forceful vomiting with subcutaneous emphysema, diagnosed by CT chest/esophagram.
Hiatal Hernia → Postprandial epigastric discomfort and reflux symptoms, differentiated by barium swallow or EGD.
RUQ pain DDX
Acute Cholecystitis → Persistent RUQ pain with fever, nausea, and positive Murphy sign, diagnosed by RUQ ultrasound showing wall thickening/pericholecystic fluid.
Biliary Colic → Intermittent RUQ pain after fatty meals without fever or leukocytosis, differentiated by gallstones on RUQ ultrasound.
Choledocholithiasis → RUQ pain with jaundice and elevated bilirubin/ALP, diagnosed with MRCP or ERCP showing CBD stone.
Ascending Cholangitis → RUQ pain with fever and jaundice (Charcot triad), diagnosed by cholestatic labs and biliary dilation on imaging.
Hepatitis → RUQ pain/discomfort with fatigue, jaundice, nausea, and dark urine, differentiated by markedly elevated AST/ALT.
Liver Abscess → RUQ pain with fever, chills, and systemic illness, diagnosed by CT/ultrasound showing hepatic abscess.
Pancreatitis → Epigastric/RUQ pain radiating to the back with nausea/vomiting, diagnosed with elevated lipase.
Peptic Ulcer Disease → Burning epigastric/RUQ pain related to meals with possible GI bleeding, diagnosed with H. pylori testing and EGD.
Fitz-Hugh–Curtis Syndrome → RUQ pain in sexually active women with PID symptoms, differentiated by pelvic findings and STI testing.
Right Lower Lobe Pneumonia → RUQ pain with cough, fever, and hypoxia, diagnosed by chest X-ray infiltrate.
Pulmonary Embolism → Pleuritic RUQ/chest pain with tachycardia or hypoxia, diagnosed by CTA chest.
Pyelonephritis → RUQ/flank pain with fever, dysuria, and CVA tenderness, diagnosed by UA and urine culture.
Nephrolithiasis → Colicky RUQ/flank pain radiating to groin with hematuria, diagnosed by CT stone protocol.
Subphrenic Abscess → RUQ pain with fever and recent surgery/infection history, diagnosed by CT abdomen.
Congestive Hepatopathy → RUQ discomfort with JVD, edema, and heart failure signs, differentiated by hepatic congestion on imaging/labs.
Budd-Chiari Syndrome → RUQ pain with hepatomegaly and ascites, diagnosed by hepatic vein thrombosis on Doppler ultrasound/CT.
Herpes Zoster → Burning RUQ pain followed by dermatomal vesicular rash, diagnosed clinically.
ACS / Inferior MI → RUQ/epigastric discomfort with diaphoresis or exertional symptoms, diagnosed with EKG and troponins.
Aortic Dissection → Sudden severe RUQ/chest/back pain with pulse deficits or neurologic findings, diagnosed by CTA.
HELLP Syndrome (pregnancy) → RUQ pain in pregnancy with hypertension and elevated LFTs/platelets low, diagnosed with CBC/LFTs.
Gallbladder Cancer → Chronic RUQ pain with weight loss and jaundice, differentiated by mass/imaging abnormalities.
RUQ pain DDX
Splenic Infarct → Sudden LUQ pain often with AFib or hypercoagulable history, diagnosed by CT abdomen with contrast.
Splenic Rupture → Severe LUQ pain after trauma with hypotension or Kehr sign (left shoulder pain), diagnosed by FAST exam or CT.
Splenomegaly → LUQ fullness/discomfort with early satiety, differentiated by enlarged spleen on exam/imaging.
Pancreatitis → LUQ/epigastric pain radiating to the back with nausea/vomiting, diagnosed by elevated lipase.
Pancreatic Cancer → Persistent LUQ/epigastric pain with weight loss and jaundice, differentiated by CT pancreas protocol.
Gastritis → Burning LUQ/epigastric pain with nausea or NSAID/alcohol history, diagnosed with H. pylori testing or EGD.
Peptic Ulcer Disease → Gnawing LUQ/epigastric pain related to meals with possible melena, diagnosed by EGD and H. pylori testing.
Perforated Ulcer → Sudden severe LUQ/epigastric pain with rigid abdomen/peritonitis, differentiated by free air on imaging.
GERD → Burning upper abdominal/chest discomfort worse lying flat or after meals, improves with antacids/PPI.
Left Lower Lobe Pneumonia → LUQ pain with cough, fever, and hypoxia, diagnosed by chest X-ray infiltrate.
Pulmonary Embolism → Pleuritic LUQ/chest pain with tachycardia or dyspnea, diagnosed by CTA chest.
Pyelonephritis → LUQ/flank pain with fever, dysuria, and CVA tenderness, diagnosed by UA and urine culture.
Nephrolithiasis → Colicky LUQ/flank pain radiating to groin with hematuria, diagnosed by CT stone protocol.
Mesenteric Ischemia → Severe abdominal/LUQ pain out of proportion to exam often with AFib history, diagnosed by elevated lactate and CTA.
Small Bowel Obstruction → Crampy LUQ abdominal pain with vomiting and distention, diagnosed by CT showing dilated bowel loops.
IBS / Functional Dyspepsia → Chronic LUQ discomfort with normal labs/imaging and relation to stress or bowel habits, diagnosed clinically after exclusion.
Herpes Zoster → Burning LUQ pain followed by dermatomal vesicular rash, diagnosed clinically.
ACS / Inferior MI → LUQ/epigastric discomfort with diaphoresis or exertional symptoms, diagnosed with EKG and troponins.
Aortic Dissection → Sudden tearing chest/LUQ/back pain with pulse deficits, diagnosed by CTA.
Subphrenic Abscess → LUQ pain with fever and recent surgery/infection history, diagnosed by CT abdomen.
LLQ pain DDX**
Diverticulitis → LLQ pain with fever, constipation, or diarrhea in older adults, diagnosed by CT abdomen/pelvis showing colonic inflammation.
Constipation → Crampy LLQ discomfort with decreased bowel movements and bloating, differentiated by stool burden on exam/X-ray.
Colitis → LLQ pain with diarrhea and possible blood/mucus in stool, diagnosed by CT and stool studies.
Inflammatory Bowel Disease → Chronic LLQ pain with diarrhea, weight loss, and hematochezia, diagnosed with colonoscopy and biopsies.
Ischemic Colitis → Sudden LLQ pain with bloody diarrhea in older patients/vascular disease, diagnosed by CT or colonoscopy.
Small Bowel Obstruction → Crampy LLQ abdominal pain with vomiting and distention, diagnosed by CT showing dilated bowel loops.
Sigmoid Volvulus → Abdominal distention with LLQ pain and constipation/obstipation, differentiated by “coffee bean” sign on imaging.
Nephrolithiasis → Colicky LLQ/flank pain radiating to groin with hematuria, diagnosed by CT stone protocol.
Pyelonephritis → LLQ/flank pain with fever, dysuria, and CVA tenderness, diagnosed by UA and urine culture.
Urinary Tract Infection → Suprapubic/LLQ discomfort with dysuria and urinary frequency, diagnosed by urinalysis.
Inguinal Hernia → LLQ/groin pain with bulge worse on standing or coughing, diagnosed clinically or with ultrasound.
Ovarian Torsion → Sudden severe LLQ pain with nausea/vomiting in women, diagnosed by pelvic ultrasound with Doppler.
Ectopic Pregnancy → LLQ pain with vaginal bleeding and missed period, differentiated by positive β-hCG and transvaginal ultrasound.
Ovarian Cyst Rupture → Sudden unilateral LLQ pelvic pain often after exertion/intercourse, diagnosed by pelvic ultrasound.
Pelvic Inflammatory Disease → LLQ/pelvic pain with fever, discharge, and cervical motion tenderness, diagnosed clinically with STI testing.
Endometriosis → Cyclic LLQ/pelvic pain associated with menses and dyspareunia, diagnosed clinically/laparoscopy.
IBS → Chronic LLQ pain associated with bowel habit changes relieved by defecation, diagnosed clinically after exclusion.
Mesenteric Ischemia → Severe LLQ abdominal pain out of proportion to exam, diagnosed with elevated lactate and CTA.
Abdominal Aortic Aneurysm → LLQ/back pain with hypotension or pulsatile mass in older patients, diagnosed by ultrasound or CTA.
Herpes Zoster → Burning LLQ pain followed by dermatomal vesicular rash, diagnosed clinically.
RLQ pain DDX**
Appendicitis → RLQ pain migrating from periumbilical area with nausea, anorexia, and fever, diagnosed by CT abdomen/pelvis or ultrasound.
Mesenteric Adenitis → RLQ pain with recent viral illness and lymphadenopathy, differentiated by enlarged mesenteric nodes on CT.
Crohn Disease → Chronic RLQ pain with diarrhea, weight loss, and fistulas, diagnosed by colonoscopy with biopsies.
Cecal Diverticulitis → RLQ pain with fever and leukocytosis mimicking appendicitis, diagnosed by CT abdomen/pelvis.
Constipation → Crampy RLQ discomfort with decreased bowel movements and bloating, differentiated by stool burden on imaging/exam.
Small Bowel Obstruction → Crampy RLQ abdominal pain with vomiting and distention, diagnosed by CT showing dilated bowel loops.
Nephrolithiasis → Colicky RLQ/flank pain radiating to groin with hematuria, diagnosed by CT stone protocol.
Pyelonephritis → RLQ/flank pain with fever, dysuria, and CVA tenderness, diagnosed by UA and urine culture.
Urinary Tract Infection → Suprapubic/RLQ discomfort with dysuria and urinary frequency, diagnosed by urinalysis.
Inguinal Hernia → RLQ/groin pain with bulge worse on standing or coughing, diagnosed clinically or with ultrasound.
Ovarian Torsion → Sudden severe RLQ pelvic pain with nausea/vomiting, diagnosed by pelvic ultrasound with Doppler.
Ectopic Pregnancy → RLQ pain with vaginal bleeding and missed period, differentiated by positive β-hCG and transvaginal ultrasound.
Ovarian Cyst Rupture → Sudden unilateral RLQ pelvic pain often after intercourse/exertion, diagnosed by pelvic ultrasound.
Pelvic Inflammatory Disease → RLQ/pelvic pain with fever, discharge, and cervical motion tenderness, diagnosed clinically with STI testing.
Mittelschmerz → Mild unilateral RLQ pelvic pain occurring mid-cycle during ovulation, diagnosed clinically.
Testicular Torsion → RLQ/groin pain with acute testicular pain/swelling and absent cremasteric reflex, diagnosed by testicular ultrasound.
Epididymitis → RLQ/groin pain with scrotal swelling and dysuria, differentiated by testicular ultrasound and UA.
Mesenteric Ischemia → Severe RLQ abdominal pain out of proportion to exam, diagnosed with elevated lactate and CTA.
Abdominal Aortic Aneurysm → RLQ/back pain with hypotension or pulsatile mass, diagnosed by ultrasound or CTA.
Herpes Zoster → Burning RLQ pain followed by dermatomal vesicular rash, diagnosed clinically.
Suprapubic pain DDX**
Urinary Tract Infection (Cystitis) → Suprapubic pain with dysuria, urinary frequency, and urgency, diagnosed by urinalysis and urine culture.
Pyelonephritis → Suprapubic pain with fever, flank pain, nausea, and CVA tenderness, diagnosed by UA and urine culture.
Urinary Retention → Suprapubic pain/fullness with inability to void and distended bladder, diagnosed by bladder scan/post-void residual.
Nephrolithiasis → Suprapubic/groin pain with hematuria and colicky symptoms, diagnosed by CT stone protocol.
Interstitial Cystitis → Chronic suprapubic pain worsened by bladder filling and relieved with urination, diagnosed clinically after exclusion.
Prostatitis → Suprapubic/perineal pain with dysuria, fever, and tender prostate, diagnosed clinically with UA/culture.
Benign Prostatic Hyperplasia (BPH) → Suprapubic discomfort with weak stream, hesitancy, and incomplete emptying, differentiated by elevated post-void residual.
Pelvic Inflammatory Disease → Suprapubic/pelvic pain with vaginal discharge, fever, and cervical motion tenderness, diagnosed clinically with STI testing.
Ectopic Pregnancy → Suprapubic/pelvic pain with vaginal bleeding and missed period, diagnosed by β-hCG and transvaginal ultrasound.
Ovarian Torsion → Sudden severe suprapubic/unilateral pelvic pain with nausea/vomiting, diagnosed by pelvic ultrasound with Doppler.
Ovarian Cyst Rupture → Sudden pelvic/suprapubic pain often after exertion/intercourse, diagnosed by pelvic ultrasound.
Endometriosis → Cyclic suprapubic/pelvic pain associated with menses and dyspareunia, diagnosed clinically/laparoscopy.
Fibroids → Chronic suprapubic pressure/pain with heavy menstrual bleeding, differentiated by pelvic ultrasound.
Appendicitis (pelvic appendix) → Suprapubic pain with nausea, fever, and leukocytosis, diagnosed by CT abdomen/pelvis.
Diverticulitis → Suprapubic/LLQ pain with fever and bowel changes, diagnosed by CT abdomen/pelvis.
Constipation → Crampy suprapubic discomfort with bloating and decreased bowel movements, differentiated by stool burden on exam/imaging.
IBS → Chronic suprapubic abdominal pain associated with bowel habit changes relieved by defecation, diagnosed clinically after exclusion.
Bladder Cancer → Suprapubic discomfort with painless hematuria especially in smokers, diagnosed by cystoscopy and imaging.
Urethritis/STI → Suprapubic discomfort with dysuria and urethral discharge, diagnosed by STI testing.
Abdominal Wall Strain → Localized suprapubic pain worse with movement or palpation, diagnosed clinically.
Suprapubic pain DDX**
Gastroenteritis → Diffuse abdominal pain with nausea, vomiting, diarrhea, and sick contacts, usually diagnosed clinically.
Small Bowel Obstruction → Diffuse crampy abdominal pain with vomiting, distention, and obstipation, diagnosed by CT showing dilated bowel loops.
Large Bowel Obstruction → Diffuse abdominal pain with severe distention and constipation, differentiated by CT showing colonic dilation.
Mesenteric Ischemia → Severe diffuse abdominal pain out of proportion to exam often with AFib history, diagnosed by elevated lactate and CTA.
Peritonitis / Perforated Viscus → Sudden diffuse abdominal pain with rigid abdomen and rebound tenderness, diagnosed by free air on imaging.
Sepsis → Diffuse abdominal discomfort with fever, hypotension, and tachycardia, differentiated by infectious workup and elevated lactate.
Pancreatitis → Diffuse/epigastric abdominal pain radiating to the back with nausea/vomiting, diagnosed by elevated lipase.
DKA → Diffuse abdominal pain with vomiting, polyuria, and altered mentation, diagnosed by anion-gap metabolic acidosis and ketones.
Constipation → Diffuse crampy abdominal discomfort with bloating and decreased bowel movements, differentiated by stool burden on imaging/exam.
Ileus → Diffuse abdominal pain/distention with decreased bowel sounds after surgery or illness, diagnosed by diffuse bowel dilation without transition point.
IBS → Chronic diffuse abdominal pain associated with bowel habit changes relieved by defecation, diagnosed clinically after exclusion.
Inflammatory Bowel Disease → Diffuse abdominal pain with chronic diarrhea, weight loss, and hematochezia, diagnosed with colonoscopy and biopsies.
Colitis → Diffuse abdominal pain with diarrhea and possible blood/mucus in stool, diagnosed with CT and stool studies.
Ischemic Colitis → Diffuse/lower abdominal pain with bloody diarrhea in older vascular patients, diagnosed by CT or colonoscopy.
Appendicitis (early) → Initially diffuse/periumbilical pain migrating later to RLQ, diagnosed by CT or ultrasound.
Abdominal Aortic Aneurysm → Diffuse abdominal/back pain with hypotension or pulsatile mass, diagnosed by ultrasound or CTA.
Aortic Dissection → Sudden severe chest/back/abdominal pain with pulse deficits, diagnosed by CTA.
Opioid Withdrawal → Diffuse abdominal cramping with diarrhea, yawning, sweating, and myalgias, diagnosed clinically.
Sickle Cell Crisis → Diffuse abdominal pain with anemia and vaso-occlusive symptoms, diagnosed clinically with supportive labs.
Acute Intermittent Porphyria → Recurrent diffuse abdominal pain with neurologic or psychiatric symptoms, diagnosed by elevated urine porphobilinogen.
Acute Abdominal pain
yo M/F with PMH of , presenting with
days constant/intermitent progressively worsening/improving
CC: Epigastric pain
PP:
PN:
pertinent SHx: tobacco, EtOH, drug use
Right Upper Quadrant (RUQ)
Pertinent Positives
Fever/chills → cholangitis/cholecystitis
Fatty food trigger → biliary colic
Jaundice/dark urine → obstruction/hepatitis
Murphy sign → cholecystitis
Radiation to back/right shoulder → biliary/pancreas
Cough/SOB → pneumonia/PE
Pertinent Negatives
No jaundice
No fever
No alcohol use
No chest pain
No urinary symptoms
Main Labs
CBC → infection
CMP/LFTs → biliary/hepatic pattern
Lipase → pancreatitis
Troponin/EKG → ACS
UA → renal source
Hepatitis panel if transaminitis
Main Imaging
RUQ ultrasound = FIRST LINE
CT abdomen/pelvis if unclear
MRCP/ERCP if obstruction concern
CXR if pulmonary symptoms
Left Upper Quadrant (LUQ)
Pertinent Positives
Pain radiating to back → pancreatitis
Trauma → splenic injury
Early satiety → splenomegaly
Fever/cough → pneumonia
AFib history → splenic infarct
Pertinent Negatives
No trauma
No alcohol use
No GI bleeding
No chest pain
Main Labs
CBC
CMP
Lipase
Troponin/EKG
Lactate if ischemia concern
Main Imaging
CT abdomen/pelvis
Lipase-directed pancreatitis workup
CXR if pulmonary symptoms
Ultrasound if splenic concern
Right Lower Quadrant (RLQ)
Pertinent Positives
Migration from periumbilical → appendicitis
Fever/anorexia → appendicitis
Diarrhea/weight loss → Crohn disease
Dysuria/hematuria → stone/UTI
Testicular pain → torsion
Vaginal bleeding/discharge → gyn pathology
Pertinent Negatives
No urinary symptoms
No vaginal bleeding
No diarrhea
No prior abdominal surgery
Main Labs
CBC
CMP
UA
β-hCG in women
CRP/ESR sometimes
STI testing if PID concern
Main Imaging
CT abdomen/pelvis = adults
Ultrasound = pregnancy/young pts
Pelvic ultrasound if ovarian concern
Testicular ultrasound if torsion concern
Left Lower Quadrant (LLQ)
Pertinent Positives
Fever → diverticulitis
Constipation/bloating → constipation/SBO
Bloody diarrhea → ischemic colitis/IBD
Dysuria/hematuria → stone/UTI
Weight loss/chronic diarrhea → IBD
Pertinent Negatives
No GI bleeding
No urinary symptoms
No prior diverticulitis
No vomiting
Main Labs
CBC
CMP
UA
Lactate if ischemia concern
Stool studies if diarrhea
Main Imaging
CT abdomen/pelvis = best initial
Colonoscopy later for IBD/ischemia (not acute diverticulitis)
Suprapubic Pain
Pertinent Positives
Dysuria/frequency → cystitis
Retention/incomplete emptying → BPH/retention
Vaginal discharge → PID
Vaginal bleeding → ectopic
Fever/flank pain → pyelo
Pertinent Negatives
No hematuria
No vaginal bleeding
No back pain
No urinary retention history
Main Labs
UA + urine culture
CBC
CMP
β-hCG
STI testing
Main Imaging
Bladder scan
Pelvic ultrasound
CT if unclear/stone concern
Epigastric Pain
Pertinent Positives
Burning/reflux → GERD
Worse with meals → PUD/gastritis
Radiates to back → pancreatitis
Exertional/diaphoresis → ACS
Melena → ulcer/GI bleed
Alcohol use → pancreatitis/gastritis
Pertinent Negatives
No chest pain
No NSAID use
No alcohol use
No GI bleeding
Main Labs
CBC
CMP/LFTs
Lipase
Troponin/EKG
Lactate if ischemia concern
Main Imaging
RUQ ultrasound
CT abdomen/pelvis
EGD later if chronic/alarm symptoms
Diffuse Abdominal Pain
Pertinent Positives
Vomiting/distention → SBO
Diarrhea → gastroenteritis/colitis
Pain out of proportion → mesenteric ischemia
Rigidity/rebound → perforation/peritonitis
Polyuria/polydipsia → DKA
Obstipation → obstruction
Pertinent Negatives
No fever
No GI bleeding
No prior surgery
No AFib history
Main Labs
CBC
CMP
Lipase
Lactate
VBG/ABG
Troponin/EKG
UA
β-hCG
Blood cultures if septic
Main Imaging
CT abdomen/pelvis with contrast = most important
Upright CXR if perforation concern
CTA if mesenteric ischemia/dissection concern
initial DATA:
pending DATA:
MEDS:
COURSE:
Plan :